Rapid Response Research Solution

Rapid Response Research Centre

~~COVID-19~~ Outbreak and Crises Solutions

Considering the long-term effect of COVID-19, we propose to quickly establish a RaReRC to focus on bringing a diverse group of scientists, mathematicians, economists, sociologists, policymakers, educators and the public to put forward a persistent effort to specialise in outbreaks. The centre will excel on topics which are hard to tackle with existing facilities and by conventional means. Keeping this long-term vision in mind, our short-term vision to develop a strategic programme for COVID-19 will be based on COVID-19 PCR Speciality, Low-Cost And Less-Chemically Involved Rapid Diagnosis, Rapid Isolation, Personal Protection, Applied Modelling Integrating Epidemic Test Results, Novel Architecture, Social Integration, Socioeconomics of Pandemic, and Distributed and Insourcing Research. These short-term plan of RaReRC is planned for immediate societal impact where all the sections will have output in terms of one months to six months with an intention of serving the country on COVID-19 until five years with aim of eradicating COVID-19 from the country and prepare ourselves for next outbreaks.

29 April 2021: We are organising an emergency meeting to create a roadmap to support India's crisis in any small way possible. Please drop us an email at create@openacademicresearch.org if you are interested in joining this meeting. During the first outbreak, we have supported the state of West Bengal. We have submitted a comprehensive proposal to the Department of Science and Technology, India, which will be shared in this meeting for further development to handle this kind of crisis from the research and development perspectives.

Plasma-flame oxygen sensor - low cost plug in device for oxygen level monitoring in gas

- Status - TRL 4 ready
- Funding source - OAR

Real-time monitoring of zeolite and novel zeolite development - local high quality production of zeolites for oxygen concentration

- Status - TRL 1 ready
- Funding source - none

Piezoelectric energy harvesting from oxygen concentrator and ventilators - clean energy supply to operate in electrical appliances without natural resources, like solar, wind, or hydro energy

- Status - TRL 8 ready
- Funding source - The Ministry of Education, formerly the Ministry of Human Resource Development, and Indian Institute of Science Bangalore Bangalore

Sustainable oxygen concentrator using recycled water bottles - providing design that is suitable to reuse used plastic-based water bottles with automatic feedback pressure swing mechanism

- Status - TRL 4 ready
- Funding source - OAR

Universal nanofluidic device - fast detection of virus and a novel tools for researchers and industries to study visual and drugs

- Status - TRL 8 ready
- Funding source - various international sources for proof of concept development; the Government of Karnataka through Indian Institute of Science Bangalore and International Centre for Nanodevices Private Limited.

Surface diffusion of SARS CoV viruses - a physical tool for diagnostics and research of viruses without expensive biochemistry

- Status - TRL 6 ready
- Funding source - German Research Foundation

Image processing of complex pattern formation in lung - fast evolution of COVID and lung structures identification with sound processing

- Status - TRL 7 ready
- Funding source - OAR

Nanorobotic mobile implant for early diagnosis and target therapy - COVID and other terminal illnesses require continuous monitoring at high resolution and feedback drug delivery for side effect free fast cure

- Status - TRL 4 ready
- Funding source - German Research Foundation, Max Planck Society, and Lower Saxony Ministry of Science and Culture

SASMolution - a non-toxic low-cost microbiological grade sanitiser for COVID and non-COVID infection prevention

- Status - TRL 9 ready
- Funding source - OAR

Thin-film surface engineering and self-cleaning of mask - a plasma processing based thin film preparation for sustainable material development for high efficacy mask

- Status - TRL 3 ready
- Funding source - various Government funding sources

Development of FDA Approved Open Source Ventilator

- Status - FDA Approved, consortium - LifeMech/Intel Group, Open Academic Research, University of Cambridge.

Oxtrator: Oxygen Concentrator

The only current palliative care for COVID-19 is oxygen therapy. OAR is working on an open-source oxygen concentrator to produce 98% oxygen with 8 liters per minute.

Opensource Single-Virus Microscopy Add-on

Low-cost Less-chemically involved Rapid Biophysical POC diagnosis of COVID-19 .

RaReDeLi /Rapid Response Decent Living: A Unified Multidisciplinary Dashboard Solution for India's Sustainable Socioeconomic Growth

When the world is about to experience the worst recession after the WW-II, have we wondered how to sustainably develop good health, well-being and economics in a weakened/complex socioeconomic condition in India? India is the largest democracy and home of poor billions. The COVID-19 pandemic has brought a humongous problem in India where prior non-uniformly distributed wealth, health and education were prevailing. The 2020-2021 Indian economy is expected to shrink by 3.2% according to the World Bank. The current 'Unlock-I' was intended to ease this economic downfall while on 08/06/2020 2.56K COVID-19 cases have made India as 5th largest affected country. RaReDeLi proposes to develop a unified multidisciplinary/dashboard solutions of essential product marketing in India during and after the pandemic. Globally, India is the second-largest technology market. 90.15% of the Indian population uses mobile phones and 25% uses smartphones. We will create a multidimensional matrix by deploying portable ventilator as a therapeutic technology, sanitiser as a personal protection method, diagnostic sensor, and software for social communication. We will trial technologies being developed for COVID-19 and its dissemination for social development in India. Four kinds of COVID-19 product lines will be trialled for their long-term sustainability.

NanoSMoS: Nanofluidic Single-Molecule Sensitive Sensor for Domestic Spread of Carcinogens and Airborne Pathogens

Disease like cancer and pandemics cause huge long-term economic impact and raises a big question on the survival of human race. Our vision is to make public aware of the root cause of these diseases and empower them to monitor it at home like, a CO sensor but at the ultimate sensitivity. A single molecule of carcinogens and a single pathogen is sufficient to trigger the terminal illness. Many such detrimental compounds and microorganisms can be avoided at early stage. Thus, we aim to develop a domestic pollution sensor to monitor domestic organic carcinogens at single-molecule sensitivity. Since the sensors will be single-molecule sensitive it will be suitable for secondary detection of lethal airborne pathogens and nanoparticles, which falls under particulate matter. The particular need of this sensors are for the low-income housings in densely populated countries and fundamental investigation of material science and molecular biology research.

Early detection and prediction of COVID-19

COVID-19 outbreak requires attention from multilateral collaboration. Science and technology have gone to the level of achievements that diverse background of expertise can come to a table to bring forward solution together in an urgent situation, like COVID-19 outbreak. We would like to translate our scientific understanding of virology, single-molecule detection, single-virus detection, biophysics, optics, statistical physics, electron-optics, and artificial intelligence to eliminate false-negative detections, and thereby, prevent the human-rights violation at South Asian countries. We are proposing to take a novel path of biophysical detection to avoid large costs involved for chemicals and biomolecules in genome analysis-based identification of nCoV. Beside low-cost, the proposed method can identify nCoV in a high throughput manner. We will also reach out to the public to make them understand the need for early diagnosis.

SASMolution: A microbiologically relevant sanitizer

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SASMolution is a microbiologically relevant sanitizer that is used in BSL3/CL2 labs where viruses are handled. The solution coagulates protein at an optimal rate so that it can permeate through microbial cells before coagulation can block SASMolution; leading to the entire microbial cell death. The formula used here is most effective in killing microbes. Higher or lower concentration of the solution is not so effective in killing microbes.

SASMolution does not contain any artificially synthesised colour or essence; the added colour and essence are extracted from orange peel and water lily using only biocompatible organic chemistry.

SASMolution is packaged in spray bottles since a similar method is used in the labs as well. It will spray an optimal amount of SASMolution that will also enable large longevity than any conventional sanitisers in the market.

During the public health emergency of international concern, SASMolution is developed and prepared by scientists from the University of Cambridge, Utrecht University, Leiden University and Indian Institute of Technology Bombay under the unique platform of Rapid Response Research Solution of Open Academic Research.

Open Academic Research is registered in the UK as Open Academic Research UK CIC and in India as Open Academic Research Council.

Where is COVID-19 taking us?

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